What Is Adenocarcinoma

UK Study Links Dietary Fat to Esophageal Cancer Risk

CHICAGO – Total dietary fats and saturated fatty acids were found to be positively associated with esophageal adenocarcinoma, but not with Barrett’s esophagus, in a prospective cohort study reported at the annual Digestive Disease Week.

"The role of fats may therefore be important in the change from metaplasia into neoplasia," said principal investigator Dr. Max Yates of the Norfolk and Norwich (England) University Hospital. "Dietary fats and saturated fats should therefore be measured in future etiological studies of adenocarcinoma."

The study, funded by Cancer Research UK and the U.K. Medical Research Council, was intended to evaluate the role of dietary fat in the etiology of Barrett’s esophagus and esophageal adenocarcinoma. Barrett’s esophagus is characterized by metaplastic change in the cells of the lower esophagus, Dr. Yates said, and is recognized as a risk factor for esophageal adenocarcinoma.

A prospective cohort design was selected because the alternative case-control designs are subject to recall bias and selection bias, which can lead to inaccuracies in the dietary information.

The cohort was recruited from the EPIC (European Prospective Investigation into Cancer and Nutrition) Norfolk county database. The EPIC study overall has recruited over 500,000 participants in 10 countries, and the EPIC-Norfolk cohort consists of 23,750 participants (aged 45-74 years) from rural, suburban, and inner-city areas.

There were three groups in the study: 3,667 randomly selected controls, 100 cases of Barrett’s esophagus, and 61 cases of esophageal adenocarcinoma. Controls were about the same age as were patients with Barrett’s esophagus (median, 59-60 years at recruitment), whereas those with esophageal adenocarcinoma were about 7 years older (median, 67 years). More than 80% of both groups were male. In this prospective cohort, the median age at diagnosis was 67 years for the Barrett’s patients and 73 years for the esophageal adenocarcinoma patients.

At enrollment and with the help of a nutritionist, participants began a 7-day food diary, which is "the most accurate, validated form of pragmatic nutritional assessment in large-scale epidemiological studies," said Dr. Yates. Patients recorded all food and beverages consumed, along with brands, portion sizes, and recipes. The diaries were coded using the DINER (Data Into Nutrients for Epidemiological Research) computer program.

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Is spread from her former breast cancer? it sounds like they think it is because they want to treat it with estrogens. if it is hormone responsive, she has a much better chance. if they don’t respond to hormones, her outlook really isn’t as good. the fact that her previous cancer spread to two other places is not a very good sign.

and don’t worry about the chemo only being one time per month. different kinds are on different schedules.

I dont want to alarm you. But my mother had breast cancer and it spread into her s after being told 4 years earlier that she was cancer free. After her dignosis in May of 2003, sadly it took intill Dec of 2004 to kill her. She was only 49. They tried everything from chemo to radiation. They even had her on a hormone pill but the cancer had just spread so much. I am really sorry about your friend my heart goes out to her. I would find out what stage she is in. My mother was in stage four so there was really not much they could do. Through the treatments they provided it did prolong her life for a year and half after given a timeline of 6 months. And again I am truly sorry about your friend.

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